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Pipeline

AlloMAp Platform Programs

ProgramIndicationDiscoveryLead OptimizationPreclinicalClinical
AST-101T1DM/T2DM    
AST-102T2DM    

BiFAp Platform Programs

ProgramIndicationDiscoveryLead OptimizationPreclinicalClinical
AST-201Liver cancer    
AST-202AMD, DR    
AST-203GMB    
AST-301DM    
AST-302Parkinson’s disease    

AST-101

Allosteric agonist aptamer to insulin receptor without side effects

- Low weight gain / Reduced CVD/cancer risks
- No insulin-induced insulin resistance

AST-101

AST-101 developmental status

- Selected “ Big Pharma Joint R&D Program “ and supported by Korea Drug Development Fund(KDDF)
· Discovery (KDDF201601-04)
· Preclinical (KDDF201809-05)
- 2020 4Q : IND filing & Phase I study

AST-102

Development of the insulin sensitizer with novel MoA

- Reduced risk of insulin-induced hypoglycemia
- Effective glycemic control by improving insulin sensitivity

AST-102

AST-102 developmental status

AST-201

Unmet needs for liver cancer

- Ranks 12th on Incidence rate, ranks 4th on mortality rate
- High unmet medical needs

AST-201

- GPC3-targeted BiFAp aptamer incorporated with gemcitabine
- Anti-cancer effect specific to GPC3-expressing hepatocellular carcinoma cells

AST-201 development status

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