About Aptamer

Aptamers, also known as chemical antibodies, are short single-stranded oligonucleotide molecules that selectively bind to specific targets including proteins, peptides, and carbohydrates. Aptamers recognize and bind targets by a 3-dimensional structure, while antibodies recognize linear epitopes of the targets. Since they are chemically synthesized, the process can simply be scaled-up, there are low batch-to-batch variation and high stability. Besides, the production of the aptamer is fast and cost-effective. Aptamers are highly safe biomaterials with no reported in vivo immunogenicity.

CharacteristicCompositionNucleic Acid (ss DNA/RNA)
Epitopes3D-structural interactions
SizeSmall size ~20kDa
ImmunogenicityNo Immunogenicity
DiscoveryTargetVarious small molecules including proteins
Discovery time6~8 weeks
ProductionProductionChemical synthesis
StorageStore at any temperature
EpitopesLinear epitope of target
SizeLarge size ~150kDa
ImmunogenicityHigh incidence of immunogenicity
DiscoveryTargetProtein antigen
Discovery timeSeveral months
ProductionProductionBiological production
StorageStore at 4°C ~ -20°C